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KMID : 0356619920070010061
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Journal of Korean Society of Endocrinology
1992 Volume.7 No. 1 p.61 ~ p.65
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Adrenal Function in Active Pulmonary Tuberculosis
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황재석
박근용/한승범/이인규/전영준.
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Abstract
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Although tuberculosis is one of the most common causes of adrenal insufficiency, especially in Korea, little is known about adrenal function in patients with active tuberculosis. Rifampicin can also cause decreased bioavailability of
glucocorticoid
hormone related to its effect on adrenocorticosteroid metabolism consequent to hepatic enzyme induction. Forty-two Korean adults with active pulmonary tuberculosis were assessed for adrenal function before and after 4 weeks' antituberculous
chemotherapy
fall patients administerd regimens incruding rifampicin).
There was no difference in serum sodium concentration among the 3 groups, divided by response of the serum cortisol increment aftercotrosyn stimulation. (p>0.05) After the cotrosyn stimulation test, cortisol responses were subnomal in 3 patients
(7.1%),
and returned to normal in all but one patient following a 4 week course of antituberculous chemotherapy.
It is concluded that there is uncommon but definite incidence (7.1%) of adrenal dysfunction in patients with active tuberculosis. Antituberculous chemotherapy that includes riampicin does not have an adverse affect on adrenal function. (J Kor Soc
Endocrinol 7:61~65, 1992).
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